Novel contrast mechanism via ParaHydrogen SElf Rfocussing

نویسندگان

  • J. F. Dechent
  • L. Buljubasich
  • L. M. Scheiber
  • H. W. Spiess
چکیده

Figure 1: Left: three dimensional scheme of the phantom used for MRI experiments. Center tube is filled with PHIP substance (orange), outer tube contains water (blue). Right: the FIDs originating from the whole phantom. The blue signal stems from thermally polarized water and thermally polarized PHIP substanc. The red signal is generated by thermally polarized water and hyperpolarized PHIP substance exhibiting an antiphase NMR signal.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Efficient Synthesis of Nicotinamide-1-15N for Ultrafast NMR Hyperpolarization Using Parahydrogen

Nicotinamide (a vitamin B3 amide) is one of the key vitamins as well as a drug for treatment of M. tuberculosis, HIV, cancer, and other diseases. Here, an improved Zincke reaction methodology is presented allowing for straightforward and scalable synthesis of nicotinamide-1-(15)N with an excellent isotopic purity (98%) and good yield (55%). (15)N nuclear spin label in nicotinamide-1-(15)N can b...

متن کامل

Transfer of Parahydrogen-Induced Polarization to 19F:

Introduction Parahydrogen-Induced Polarization (PHIP) leads to strong signal enhancement in H-NMR if unsaturated substrates are hydrogenated with parahydrogen (p-H2) applying an appropriate catalyst. As shown before, this polarization can be transferred to heteronuclei such as C. For imaging the lung, a F-hyperpolarized contrast agent should be available, if possible for inhalation. Normally, t...

متن کامل

High-resolution spectroscopy and the analysis of ro-vibrational transitions of molecules in solid parahydrogen

Solid parahydrogen provides a novel matrix for isolation spectroscopy of atoms and molecules. Ro-vibrational motion of molecules embedded in solid parahydrogen is well quantized on account of the weak interactions in the crystal and of the softness of the crystal being characteristic of quantum crystals. Most of the observed spectral linewidths are one or two orders of magnitude sharper than th...

متن کامل

Parahydrogen Induced polarization by homogeneous catalysis: theory and applications.

The alignment of the nuclear spins in parahydrogen can be transferred to other molecules by a homogeneously catalyzed hydrogenation reaction resulting in dramatically enhanced NMR signals. In this chapter we introduce the involved theoretical concepts by two different approaches: the well known, intuitive population approach and the more complex but more complete density operator formalism. Fur...

متن کامل

Production of Catalyst-Free Hyperpolarised Ethanol Aqueous Solution via Heterogeneous Hydrogenation with Parahydrogen

An experimental approach for the production of catalyst-free hyperpolarised ethanol solution in water via heterogeneous hydrogenation of vinyl acetate with parahydrogen and the subsequent hydrolysis of ethyl acetate was demonstrated. For an efficient hydrogenation, liquid vinyl acetate was transferred to the gas phase by parahydrogen bubbling and almost completely converted to ethyl acetate wit...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010